Webinar 3 overview

  • Pediatric cancer predisposition syndromes involving non-central nervous system solid paediatric tumours: a review on their manifestations with a focus on histopathology - Ronald de Krijger
  • Update on pediatric primary liver tumors - Lola Lopez Terrada

This event will take place at 1:00pm and last approximately 1 hour.

Webinar series overview

Paediatric tumours and tumour-like malformations present unique diagnostic and therapeutic challenges due to their diverse biological behaviours and the nuances of their classification. Advances in molecular genetics and diagnostic techniques continue to reshape our understanding of these diseases, refining their characterization and expanding opportunities for targeted therapies.

The World Health Organization (WHO) and the International Agency for Research on Cancer (IARC) have officially released, for the first time in the seven decades since the “Blue Books” started, a volume (two volumes, also for the first time) with the WHO Classification of Paediatric Tumours. This landmark publication represents the culmination of years of collaborative research and expertise, offering a comprehensive framework for the classification of tumours in children and adolescents prepared by specialists in paediatric pathology in collaboration with a vast array of other pathology experts. The classification reflects the distinct pathological, molecular and clinical characteristics of paediatric tumours, emphasizing their developmental features which explain differences from their adult counterparts, and underscoring the need for age-specific diagnostic and treatment strategies (Virchows Archiv (2025) 486:1–2 https://doi.org/10.1007/s00428-025-04033-5).

In January 2025, Virchows Archives, the official journal of the European Society of Pathology published the Annual Review Issue focusing on Challenges and Novelties in Paediatric Pathology (Virchows Archiv (2025) 486).

Professor Miguel Reyes Múgica and Dr Isabel Colmenero, Editors of this special issue, succeeded in bringing together a comprehensive collection of paediatric tumours and cancer predisposition syndromes, each of which was authored by experts in the specific tumour field.

The Royal College of Pathologists is delighted to announce a webinar series organised jointly with the European Society of Pathology, Virchows Archives and the International Paediatric Pathology Association (IPPA).  Each of the topics published by  Virchows  addressing paediatric tumours will be presented at the webinars series.

We are certain this joint webinar series will attract many paediatric and general pathologists from around the world.

CPD

This meeting is worth 1 CPD point (self credited).

Speaker/chair biographies - Challenges and novelties in Paediatric Pathology (webinar 3)

  • Professor Ronald de Krijger

    Speaker

    Ronald de Krijger is a staff pathologist and Full Professor of Pathology of Solid Pediatric Tumors in both the University Medical Center Utrecht and the Princess Maxima Center for pediatric oncology, which is the national pediatric oncology center of The Netherlands, also located in Utrecht. He worked as a Professor of Pediatric and perinatal pathology at Erasmus MC, Rotterdam, The Netherlands, until he joined the abovementioned institutes in 2015 to concentrate fully on solid pediatric tumors, including liver tumors, renal tumors, neuroblastomas, and other rare solid pediatric tumors. He currently supervises 6 PhD students and a postdoc. He has been involved in the EU H2020 Chiltern project and PHITT trial, responsible for international rapid review for correct risk group assignment and chair of the international pathology review panel. In addition, he is now involved in the FKC BT4ChildLC project and in a project  awarded in 2023 by the Hanarth Foundation on deep learning techniques in pediatric renal cancer (500k, 1 PhD, 1 postdoc), together with Prof. Jeroen van der Laak, Dept of Pathology Radboud UMC, Nijmegen, The Netherlands. He has an extensive track record in cancer research, with over 350 peer-reviewed articles in pubmed, mostly related to pediatric and endocrine cancer, focussing on translational research, highlighting clinicopathological correlation and implementation of biomarkers in routine practice. He participates in the International Collaboration on Cancer Reporting committee on hepatoblastomas and on neuroblastomas (and has already done so for pheochromocytoma and adrenocortical tumors), and has been involved in several volumes of the 5th series of WHO blue books (expert for Endocrine and Neuroendocrine Tumors, contributor for Digestive System Tumours, Urinary and Male Genital Tumors, Pediatric Tumors, Genetic Tumour Sydnromes). Also he was editor of the 5th series volume of the AFIP fascicle on Adrenal Tumours.

  • Dr. Lopez-Terrada

    Speaker

    Dr. Lopez-Terrada serves as Professor of Pathology and Pediatrics at Baylor College of Medicine and Division Chief of Genomic Medicine at Texas Children’s Hospital, where she leads a diagnostic service and pediatric cancer testing reference center involved in cancer genomics, precision oncology and the development of clinical applications in these fields. She is actively involved in national and International professional societies and collaborative groups including the Children's Oncology Group (COG), the College of American Pathologists (CAP), the Association for Molecular Pathology (AMP), and the World Health Organization (WHO).

    Dr. Lopez-Terrada has dedicated her career to study the biology of pediatric neoplasms, including hematolymphoid malignancies, solid tumors and liver tumors, in particular. She is currently involved in national and international pediatric liver tumors collaborative research projects and clinical trials. She serves as Biology Co-Chair of the COG Liver Tumors Committee, Co-PI (biology) of the International Pediatric Liver Tumor Trial (PHITT) and COG Pediatric Tumors Trial (AHEP1531). She also serves as PI for a NCI UH3 award and is involved in a number of other interdisciplinary awards along with her colleagues to investigate diagnostic, prognostic and therapeutic biomarkers for pediatric liver cancer.

  • Catarina Eloy

    Chair