Professor Mariam Jamal-Hanjani will give a talk entiteled "Evolutionary nature of metastasis revealed through research autopsies"

TOPICS COVERED

Absract of the talk: TRACERx is a prospective longitudinal cancer evolution programme investigating the relationship between intratumour heterogeneity and clinical outcomes in non-small cell lung cancer (NSCLC). PEACE is a national pan cancer autopsy programme in which research autopsies have begun to shed light on evolutionary pathways in late stage disease, and combining both studies affords the unique opportunity to study cancer from diagnosis to death, in the context of the tumour, but also its microenvironment. Matched primary and metastatic tumour analyses a cohort of patients with NSCLC co-recruited in TRACERx and PEACE have demonstrated the genomic complexity of cancer relapse and metastatic heterogeneity, and the different patterns of cellular migration that aid metastatic dissemination with both primary-to-metastasis and metastasis-to-metastasis seeding. Furthermore, studies of the tumour microenvironment in this cohort have shown the distinct cellular composition between the primary and metastases, and suggest a decrease immune cell composition in metastases that could contribute to disease progression and therapy resistance.

WHO SHOULD ATTEND?

Pathologists and scientists.

SPEAKER

Professor Mariam Jamal-Hanjani

For more information, please contact: [email protected].