Bulletin references January 2024

You can read the January 2024 Bulletin here.

Gender-related health

Sex and gender disparities in access and outcomes in kidney transplantation

  1. NHS Blood and Transplant. Annual report on kidney transplantation 2022/2023. Available at: https://www.odt.nhs.uk/statistics-and-reports/organ-specific-reports/).
  2. Cozzi E, Alvarez M, Carmona M, Mahillo B, Forsythe J, Lomera M et al. An analysis by the European Committee on Organ Transplantation of the Council of Europe outlining the international landscape of donors and recipients sex in solid organ transplantation. Transplant Int 2022;35:10322.
  3. Segev D, Kucirka L, Oberai P, Parekh RS, Boulware LE, Powe NR et al. Age and comorbidities are effect modifiers of gender disparities in renal transplantation. J Am Soc Nephrol 2009;20:621–628.
  4. Couchard C, Bayat S, Villar E, Jacquelinet C, Ecochard R; REIN Registry. A new approach for measuring gender disparity in access to renal transplantation waiting lists. Transplantation 2012;94:513–519.
  5. Oniscu G, Schalkwijk, Johnson R, Brown H, Forsythe JLR. Equity of access to renal transplant waiting list and renal transplantation in Scotland: Cohort study. BMJ 2003;327:1261.
  6. Pruthi R, Robb M, Oniscu G, Tomson C, Bradley A, Forsythe JLR et al. Inequity of access to transplantation in the United Kingdom. CJASN 2020;15:830–842.
  7. Landhani M, Craig J, Wong G. Obesity and gender-biased access to deceased donor kidney transplantation. Nephrol Dial Transplant 2020;35:184–189.
  8. Patzer R, McPherson L, Wang Z, Plantinga LC, Paul S, Ellis M et al. Dialysis facility referral and start of evaluation for kidney transplantation among patients treated with dialysis in the Southeastern United States. Am J Transplant 2020: 20:2113–2125.
  9. Schaubel D, Stewart D, Morrison H, Zimmerman DL, Cameron JI, Jeffery JJ et al. Sex inequality in kidney transplantation rates. Arch Intern Med. 2000;160:2349–2354.
  10. Bromberger B, Spragan D, Hashmi S, Morrison A, Thomasson A, Nazarian S et al. Pregnancy-induced sensitisation promotes sex disparity in living donor kidney transplantation. J Am Soc Nephrol 2017;29:3025–3033.
  11. Wu D, Robb M, Watson CJE, Forsythe JLR, Tomson CRV, Cairns J et al. Barriers to living donor kidney transplantation in the United Kingdom: A national observational study. Nephrol Dial Transplant 2017;32:890–900.
  12. Lepeytre F, Dahhou M, Zhang X, Boucquemont J, Sapir-Pichhadze R, Cardinal H et al. Association of sex with risk of graft failure differs by age. J Am Soc Nephrol 2017;28:3014–3023.
  13. Vinson A, Zhang, X, Dahhou M, Susal C, Dohler B, Sapir-Pichhadze et al. Age-dependent sex differences in graft loss after kidney transplantation. Transplantation 2022;106:1473–1484.
  14. Boucquemont J, Pai ALH, Dharnidharka VR, Hebert D, Furth SL, Foster BJ. Gender differences in medication adherence among adolescent and young adult kidney transplant recipients. Transplantation 2019;103:798–806.
  15. Katz-Greenberg G and Shah S. Sex and gender differences in kidney transplantation. Semin Nephrol 2022;42:219−229.

Iron deficiency in women – the silent debilitator

  1. Daru J, Zamora J, Fernández-Félix BM, Vogel J, Oladapo OT, Morisaki N et al. Risk of maternal mortality in women with severe anaemia during pregnancy and post partum: a multilevel analysis. Lancet Glob Health 2018;6:e548–e554.
  2. The WOMAN-2 trial collaborators. Maternal anaemia and the risk of postpartum haemorrhage: a cohort analysis of data from the WOMAN-2 trial. Lancet Glob Health 2023;11:e1249–e1259.
  3. Shao J, Lou J, Rao R, Georgieff MK, Kaciroti N, Felt BT et al. Maternal serum ferritin concentration is positively associated with newborn iron stores in women with low ferritin status in late pregnancy. J Nutr 2012;142:2004–2009.
  4. Pavord S, Daru J, Prasannan N, Robinson S, Stanworth S, Girling J; BSH Committee. UK guidelines on the management of iron deficiency in pregnancy. Br J Haematol 2020;188:819–830.
  5. Lee CA. Women and inherited bleeding disorders: menstrual issues. Semin Hematol 1999;36:21–27.
  6. Johnson S, Lang A, Sturm M, O’Brien SH. Iron deficiency without anemia: A common yet under-recognized diagnosis in young women with heavy menstrual bleeding. J Pediatr Adolesc Gynecol 2016;29:628–631.

A bump in the road – addressing preventable errors to ensure safe transfusions in maternity

  1. Qureshi H, Massey E, Kirwan D, Davies T, Robson S, White J et al. BCSH guideline for the use of anti‐D immunoglobulin for the prevention of haemolytic disease of the fetus and newborn. Transfus Med 2014;24:8–20.
  2. NICE. Routine Antenatal Anti-D Prophylaxis for Women Who Are Rhesus D Negative. Accessed Dec 2023. Available at: www.nice.org.uk/guidance/ta156/chapter/2-Clinical-need-and-practice
  3. NICE. Abortion Care. Accessed Jan 2024. Available at https://www.nice.org.uk/guidance/ng140/resources/abortion-care-pdf-66141773098693
  4. NICE. Ectopic Pregnancy and Miscarriage: Diagnosis and Initial Management. Accessed Dec 2023. Available at https://www.nice.org.uk/guidance/ng126/resources/ectopic-pregnancy-and-miscarriage-diagnosis-and-initial-management-pdf-66141662244037
  5. Serious Hazards of Transfusion. Anti-D Aide Memoire. Available at: https://www.shotuk.org/wp-content/uploads/myimages/anti-D-aide-memoire-updated-August-2023.final_.pdf
  6. Serious Hazards of Transfusion. Bite No. 2 Anti-D Ig Administration. Available at: www.shotuk.org/resources/current-resources/shot-bites/
  7. Say L, Chou D, Gemmill A, Tunçalp Ö, Moller AB, Daniels J et al. Global causes of maternal death: A WHO systematic analysis. Lancet Glob Heal 2014;2:323–333.
  8. Knight M, Callaghan WM, Berg C, Alexander S, Bouvier-Colle MH, Ford JB et al. Trends in postpartum hemorrhage in high resource countries: A review and recommendations from the international postpartum hemorrhage collaborative group. BMC Pregnancy Childbirth 2009;9:55.
  9. Lennox C, Marr L. Scottish Confidential Audit of Severe Maternal Morbidity: Reducing Avoidable Harm. 10th Annual Report. Accessed Dec 2023. Available at: https://www.nhstaysidecdn.scot.nhs.uk/NHSTaysideWeb/idcplg?IdcService=GET_SECURE_FILE&dDocName=PROD_206738&Rendition=web&RevisionSelectionMethod=LatestReleased&noSaveAs=1
  10. S Narayan (Ed) D Poles et al. on behalf of the Serious Hazards of Transfusion (SHOT) Steering Group. The 2022 Annual SHOT Report (2023). Available at: https://doi.org/10.57911/WZ85-3885

Sharing our subject

Hugh Platt foundation essay prize winner: How do you think pathologists will shape healthcare over the next 75 years?

  1. Ranjan S, Jain S, Bhargava A, Shandilya R, Srivastava RK, Mishra PK. Lateral flow assay-based detection of long non-coding RNAs: A point-of-care platform for cancer diagnosis. J Pharm Biomed Anal 2021;204:114285.
  2. Nikanjam M, Kato S, Kurzrock R. Liquid biopsy: current technology and clinical applications. J Hematol Oncol 2022;15:1–14. 
  3. Koczula KM, Gallotta A. Lateral flow assays. Essays Biochem 2016;60:111–120.  
  4. Tominaga T. Rapid detection of Klebsiella pneumoniae, Klebsiella oxytoca, Raoultella ornithinolytica and other related bacteria in food by lateral-flow test strip immunoassays. J Microbiol Methods 2018;147:43–49.  
  5. World Health Organization. Zoonoses. Published 29 July 2020. Accessed 27 March 2023. Available at: www.who.int/news-room/fact-sheets/detail/zoonoses 
  6. World Health Organization. Antimicrobial resistance. Published 17 November 2021. Accessed 5 April 2023. Available at: www.who.int/news-room/fact-sheets/detail/antimicrobial-resistance 
  7. Thong WL, Zhang Y, Zhuo Y, Robins KJ, Fyans JK, Herbert AJ et al. Gene editing enables rapid engineering of complex antibiotic assembly lines. Nat Commun 2021;12:6872.  
  8. Furniss RCD, Kaderabkova N, Barker D, Bernal P, Maslova E, Antwi AA et al. Breaking antimicrobial resistance by disrupting extracytoplasmic protein folding. Elife 2022;11:e57974.  
  9. Wong KH, Sandlin RD, Carey TR, Miller KL, Shank AT, Oklu R et al. The role of physical stabilization in whole blood preservation. Sci Rep 2016;6:21023.  
  10. Rahfeld P, Withers SG. Toward universal donor blood: Enzymatic conversion of A and B to O type. J Biol Chem 2020;295:325–334.  
  11. Jamieson AJ, Brooks LSR, Reid WD, Piertney SB, Narayanaswamy BE, Linley TD. Microplastics and synthetic particles ingested by deep-sea amphipods in six of the deepest marine ecosystems on Earth. R Soc Open Sci 2019;6:180667.  
  12. Mariano S, Tacconi S, Fidaleo M, Rossi M, Dini L. Micro and nanoplastics identification: classic methods and innovative detection techniques. Front Toxicol 2021;3:636640.  
  13. Bianco V, Memmolo P, Carcagnì P, Merola F, Paturzo M, Distante C et al. Microplastic identification via holographic imaging and machine learning. Adv Intelligent Syst 2020;2:1900153.  

Paola Domizio Undergraduate essay prize winner: When the NHS was introduced, it was said that it would care for people ‘from the cradle to the grave’. 75 years later, how does this apply to pathology?

  1. Armstrong S. A Matter of Life and Death: Conversations with Pathologists. Dundee, UK: Dundee University Press Ltd, 2008.  
  2. Burton JL, Underwood J. Clinical, educational, and epidemiological value of autopsy. The Lancet 2007;369:1471–1480.  
  3. Boyd MMM. Phenylketonuria: City of Birmingham Screening Survey. BMJ 1961;1:771–773.  
  4. Pollitt RJ. Newborn blood spot screening: New opportunities, old problems. J Inherit Metabol Dis 2009;32:395–399.  
  5. Genomics England. Newborn Genomes Programme. Published 2021. Accessed 3 April 2023. Available at: www.genomicsengland.co.uk/initiatives/newborns 
  6. Nikanjam M, Kato S, Kurzrock R. Liquid biopsy: current technology and clinical applications. J Hematol Oncol 2022;15:131.  
  7. Department of Health. Report of the Second Phase of the Review of NHS Pathology Services in England. Published 2008. Accessed 26 March 2023. Available at: https://webarchive.nationalarchives.gov.uk/ukgwa 
  8. Virchow RLK. Die Cellularpathologie in ihrer Begründung auf physiologische und pathologische Gewebelehre. Berlin, Germany: August Hirschwald, 1858.  
  9. Albrow R, Kitchener H, Gupta N, Desai M. Cervical screening in England: The past, present, and future. Cancer Cytopathol 2012;120:87–96.  
  10. Landy R, Pesola F, Castañón A, Sasieni P. Impact of cervical screening on cervical cancer mortality: estimation using stage-specific results from a nested case–control study. Br J Cancer 2016;115:1140–1146.  
  11. Will RG, Ironside JW, Zeidler M, Cousens SN, Estibeiro K, Alperovitch A et al. A new variant of Creutzfeldt-Jakob disease in the UK. The Lancet 1996;347:921–925.  
  12. Ritchie DL, Peden AH, Barria MA. Variant CJD: Reflections a Quarter of a Century on. Pathogens 2021;10:1413.  
  13. Calabrese F, Pezzuto F, Fortarezza F, Hofman P, Kern I, Panizo A et al. Pulmonary pathology and COVID-19: lessons from autopsy. The experience of European Pulmonary Pathologists. Virchows Arch 2020;477:359–372.  
  14. NHS England. NHS History. Accessed 26 March 2023. Available at: www.england.nhs.uk/nhsbirthday/about-the-nhs-birthday/nhs-history/